This is how we go from single cells to people.
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MP3: https://timblais.bandcamp.com/track/evo-devo
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EVO-DEVO
Huxley
B. Mac.
Oh Carroll, Carroll
Gould, Stephen Jay yeah
D-D-D-D-Davidson and Peter
See
One cell divide and decide on a thousand fates
Did you ever figure how they know?
B. Mac.
We
Are built of modules combined in a planned out way
Each new piece must be told where to go
Oh
Now there’s a science helping us to understand
How our cells encode this architectural plan
Signalling each other with genetic tools oh
Oh yeah
Wow
Phenotype the interface for mouse and man
Genotype the files and the subprograms
What then are the switches, circuit boards and boot code?
Evo-Devo
Looking at the logic in the ways that we grow
Every gene directed by a signal key code
Proteins that can activate, enhance or veto
Evo-Devo
Signals are controlled by other genes that signal
Calculating in a network labyrinthal
Where the heart and liver and the hands and feet go
Signal mapping tells each region what it ought to be yo
With circuits so deeply built upon
They’re older than the Paleo
The Paleozoic Era baby
In a crucial pathway changes tend to get torpedoed
Where they go calamity goes
As this cyclopic sheep knows..
See down they cascade like a domino
Like you and I drosophila
The path that makes us optical
Was laid a long long time ago
Back before we blew up the cambrian like a bomb bomb
Now my eye protein can make you see out of your bom bom
And Hedgehog and its relatives like Indian and Sonic
Set up set up in a gradient on segments embryonic
Split forebrains and asymmetric parts depend upon it
Flipping on genetic switches and logic
From devo to evo
Adult and embryo
Mostly don’t evolve in the genes of the genome
Safer the mutation aimed at regulation
Keep the building blocks and swap their activation
From devo to evo
Parts have alter egos
Homologs evolved from repeats in the schema
Switch a couple bases in the proper places
You’ll be watching flies grow legs out of their faces oh yeah
Evo-Devo
Stick around for Modern Synthesis the sequel
Only by combining can a new theory grow
Evolution and development amigos
Evo-Devo
Signals trigger patterns of complexity so
Switching up the switches of a signalling node
Gives a modular and simple way to evolve
Look at how our spinal segments generate a neat row
Built on a molecular clock
One cycle, one vertebra
One vertebra one vertebra baby
Speeding up its rate is snakes’ developmental cheat code
That and where a lizard’s feet grow
They turn off distal aminos
Evo-Devo
This is how we go from single cells to people
Every generation and in life primeval
Life in variations endless and beautiful
Badaboom
From devo to evo
Larva to mosquito
Patterns are resolved as the signals proceed yo
Map out a gene with a glow tag
Kill it with a morpholino
Short oligo morpholino baby
From devo to evo
Voyage of the Beagle
Body plans evolve when proteins steer the genome
In this manner life’s beauty grows
Aesthetica in vivo
Evo-Devo
Caralho que vídeo fantástico <3
Mesmerizing!
YESSS, thank you, we need more science songs😃🥰 there are to many drama songs. Science Lover
Hello! I'm from Russia. Biology teacher. I just watched your videos and they are fire! It's a shame you don't make new videos! Are looking forward to!
Bro.. u literally deserve so much better for this..❤🎉 ,your dedications and sense of humour r truly impressive..
🎼🎶🐸🎵🐌 🎶🐕🎶
3:22
National anthem of biology
🧫🧬
WOW! That deserves a "Subscribe!"
name a better biology teach than this guy ill wait
Your masterpiece ever
Is anyone still here?😅
Edit: guess not?😢 (btw it's 3 days later
WE BE LOOKIN OUT OF OUR BOM BOMS WITH DIS ONE🔥🔥🔥🗣️🗣️🗣️
cant let gang know i fw this
Dude you deserve the next Grammy 🏆
this is so bad its somehow good.
nerd emogi is real.
Someone in 2024
Dad: You should become a biologist
Mom: You should become a musician
Sister: You should become a spanish translator
Him:
I am sending this to everyone who doesn't believe in evolution lmao.
Parents: Did you study for the AP Bio test?
Me:
Psa 14:1 KJV To the chief Musician, A Psalm of David. The fool hath said in his heart, There is no God. They are corrupt, they have done abominable works, there is none that doeth good.
🥲 I'm crying listening to it
Simplemente brillante, magnífica composición
It's just so good. I wonder which of his songs Tim is most proud of. This is sublime. One of the best videos on Youtube.
Ear worm evolving in my ear! Damn Darwin!
#1ranking of the trillion videos on this channel
3:14 is the best part , you can't convince me otherwise
What a guy! Pure genius.
Your talent is heavenly, no way🎉🙌🔥💓💓❤️❤️
1:05 umm..
idk why but thinking about the whole process of evolution and development always gets me so emotional. It's such a fragile yet beautiful process
Just so you know this video was shown to a class of 3rd year undergrads in a class about evo-devo in Quebec province.
Freakin' Brilliant, something I think every one of the tens of times I've seen this. (Thanks for introducing me to Sean B. Carroll) This deserves a grammy. Maybe an Emmy. Hell, a whole EGOT just for this.
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Œæüïśŵŷļřťðķňġċž
Ma di che parla sta canzone ?
My NEET exam is on 5th May 2024 and and i am watching this 😂
Evolution occurs very, very slowly.
Genuinely one of the best science song covers I've heard, though I probably haven't looked in the right places.
Whenever Despacito plays, these are the lyrics I hear. Had to come listen again now that they grew mouse embryos with extra pair of feet where the genitals are supposed to be… theory in practice. 😊
Could we all agreee this is one of the best science songs
This is phenomenal. Given the restraint of the topic covered and words he had to incorporate, it's better than the original